Mason Gamble was born January 16, 1986 in Chicago, Illinois as the second of two children to Tim and Sally Gamble. He was raised in Oak Park, Illinois but traveled elsewhere for much of his early career and schooling. After attending Oak Park River Forest High School, where he was a member of the football team and captain of the track team as a state-qualifying pole-vaulter, he became a National Merit Scholar Finalist and moved to Los Angeles, California, where he now resides, in order to attend the University of California Los Angeles and further pursue his passion for acting.

Mason's career began in Chicago when he landed a small role in GROUNDHOG DAY (1991) but was left on the editing room floor. Shortly after, his real break came after being awarded the role of "Dennis" in John Hughes' DENNIS THE MENACE (1993) after an immense nation wide casting call. Mason continued to work landing supporting roles in several films over the next several years; JUST IN TIME (1996), SPY HARD (1996), BAD MOON (1996), GATTACA (1997), RUSHMORE (1998) and ARLINGTON ROAD (1999). Mason's return to leading roles came in 1999 with the made for TV movie ANYA'S BELL that also landed him a Young Artist's Award. In 2001 he played the lead in A GENTLEMAN'S GAME and then made a cameo in longtime writer/director friend, Tom Rice's A RISING PLACE. After high school Mason had the pleasure of returning to the screen in Mike Meiners' THE TROUBLE WITH DEE DEE (2005). Mason's career has also consisted of several television appearances including guest star roles on EARLY EDITION (1996), ER (1997), CLOSE TO HOME (2005), CSI: MIAMI (2006) and a lead role on the short lived series, KATE BRASHER (2001). Mason is currently preparing to play the lead in the film version of Michael Murphy's classic novel, GOLF IN THE KINGDOM.